各位学者和老师：
由中国医学科学院药物研究所主办，美国哈佛大学医学院和首都医科大学合办，“2008北京衰老和神经退行性疾病国际研讨会”将于2008年10月21日至24日在北京举行。
大会将围绕衰老和神经退行性疾病的研究方法、进展、成果进行交流讨论。届时将有19位在神经系统疾病领域顶尖的世界知名专家与会，并进行大会报告，内容涉及老年痴呆、帕金森氏病、中风等衰老相关疾病。报告内容包括疾病的病理生理学研究、药理学研究和药物治疗研究的最新发现和进展。大会将为世界范围的研究者提供一个难得的交流和展示机会。
会议除大会报告外，还有壁报交流，现在开始征集会议交流论文，欢迎踊跃投稿和参会。
更多信息请登陆：www.2008bsan.org

会议邀请专家及报告题目：

Carmela R. Abraham, Ph.D., Professor of Biochemistry and Medicine, Boston University School of Medicine, Boston, MA, USA
Talk Title:
The Anti-Aging Protein Klotho in Aging and Alzheimer''s Disease.

Randall J. Bateman, M.D., Assistant Professor of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Talk Title:
Human CNS Protein Kinetics: An Approach To the Study of Alzheimer Disease.

Bruce Lamb, Ph.D., Associate Staff and Associate Professor, Department of Neurosciences, The Cleveland Clinic, Department of Genetics and Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Talk Title:
New Insights Into Alzheimer''s Disease Using Transgenic Mouse Models

Cynthia A. Lemere, Ph.D., Associate Professor of Neurology, Center for Neurologic Diseases, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA
Talk Title:
Amyloid-Beta Immunotherapy in the Prevention and Treatment of Alzheimer''s Disease

Song JianXing, Ph.D., Professor, Department of Biological Sciences, Faculty of ScienceYong Loo Lin School of Medicine and National University of Singapore, Singapore
Talk Title:
Structural Mechanism and Molecular Design to Enhance Regeneration of the Injured CNS Axons by Targeting Nogo-NgR and Eph-eprin Interfaces

Malú G. Tansey, Ph.D., Assistant Professor, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Talk Title:
Role and Regulation of TNF-Dependent Neuroinflammatory Mechanisms in Models of Parkinson’s Disease.

Kostas Vekrellis, Ph.D., Researcher C (Assistant Professor), Department of Basic Neuroscience, Laboratory for Neurodegenerative Diseases, Biomedical Research Foundation of the Academy of Athens (BFRAA), Athens, Greece
Talk Title:
Alpha-Synuclein Clearance: A Role For The Lysosome

Weiming Xia, Ph.D., Assistant Professor of Neurology, Center for Neurologic Diseases, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA
Talk Title:
Exploring Oligomeric Amyloid as an Alzheimer''s Disease Biomarker

Jau-Shyong Hong, Ph.D., Head, Neuropharmacology section Laboratory of Pharmacology NIEHS (National Institute of Environmental Health Science), USA
Talk Title:
Role of Inflammation in the Pathogenesis of Parkinson’s Disease
Models, Mechanisms, and Therapeutic Interventions.

Xiaomin Wang, M.D., Ph.D., Professor of Neurobiology, Capital Medical University, Beijing China.
Talk Title:
Neurotrophic and Neuroprotective Effects of Chinese Herb Tripterygium Wilfordii Hook F Monomers-Implication for Prevention and Therapy of Parkinson’s Disease

Gang Hu, Ph.D., Professor of Neurology, Nan Jing Medical University, Nanjing China.
Talk Title: (PD)

Biao Chen, M.D., Ph.D., Professor of Neurology, Xuanwu Hospital, Capital Medical University, Beijing China.
Talk Title: (PD)
Jianping Jia, M.D., Ph.D., Professor of Neurology, Xuanwu Hospital, Capital Medical University, Beijing China.
Talk Title: (AD)

Jianjun Wang, M.D., Ph.D., Professor of Neurology, Xuanwu Hospital, Capital Medical University, Beijing China.
Talk Title: (Stroke)

Lin Li, M.D., Ph.D., Professor of Neurology, Xuanwu Hospital, Capital Medical University, Beijing China.
Talk Title:
Experimental studies of traditional Chinese medicine to treat Alzheimer’s disease.

Jianzhi Wang Ph.D., Professor of Neurology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
Talk Title:
Tau hyperphosphorylation in cell fate decision.

Xiaoliang Wang, Ph.D., Professor of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing China.
Talk Title: (PD)

Gengtao Liu, Ph.D., Professor of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing China.
Talk Title:
Pharmacological study of the novel compound FLZ against neuro-degenerative diseases and its active mechanism.

Naihong Chen, Ph.D., Professor of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing China
Talk Title:
Overespressed-α-synuclein interfered NF-KB-mediated gene expression.

一、大会组织机构
大会组织委员会
主席：王晓良（中国医学科学院药物研究所）
Cynthia A. Lemere （美国哈佛大学医学院）
王晓民（首都医科大学）
成员：陈乃宏、Cynthia A. Lemere、石建功、王晓良、王晓民、邢若齐、庾石山、叶仙荣、朱海波、张建军
大会学术委员会
主席：刘耕陶院士（中国医学科学院药物研究所）
委员：Carmela R. Abraham、陈彪、陈乃宏、崔丽英、胡刚、贾建平、Cynthia A. Lemere、李琳、刘耕陶、盛树立、王建军、王建枝、王晓良、王晓民、吴镭、詹启敏、张均田
二、大会主题
衰老和神经退行性疾病。
三、时间和地点
2008年10月21日至24日，首都医科大学。
四、会议安排和内容
1. 大会报告: 2008年10月22日－23日。
2. 壁报交流
五、会议报名及回执
请将回执发送至2008bsan@imm.ac.cn，确认参会。
六、会议语言：英语
七、征文内容和要求：
衰老和神经退行性疾病相关基础和临床研究。征文要求见附件。
八、投稿方式：
参会摘要用Word编辑，通过电子邮件以附件的方式投稿，电子邮件地址为2008bsan@imm.ac.cn，请注明“2008国际衰老会”?；蛴始闹帘本┫扰┨辰?号中国医学科学院药物研究所，100050（石桥桥收）。遴选出的优秀论文将推荐至《药学学报》发表。
九、征文截止日期：
2008年9月22日。
十、会议注册费：
1. 标准一：2008年9月12日以前，1200元/人
2008年9月13日至10月23日，1500元/人
2. 标准二：全日制学生在读研究生（报道时需提供学生证）
2008年9月12日以前，600元/人
2008年9月13日至10月23日，800元/人
3. 帐户：
收款单位：中国医学科学院药物研究所
开户银行：中国工商银行珠市口支行
帐号：891004-89
请注名：2008国际衰老会及参会者姓名和身份
联系人：石桥桥，010-63165193, shiqiaoqiao@imm.ac.cn

中国医学科学院药物研究所
2008年6月25日

附件：

2008北京衰老和神经退行性疾病国际研讨会回执

注：参加会议者请将回执发送至2008bsan@imm.ac.cn，或邮寄至中国医学科学院药物研究所，北京市先农坛街1号，100050，石桥桥收。

2008北京衰老和神经退行性疾病国际研讨会
英文摘要书写格式

摘要（包括题目、作者姓名、单位等在内）400字左右。
题目及正文12号字，字体Times New Roman, 题目大写并加粗。
作者姓名：中国作者姓名用汉语拼音（格式：LI Xiang-Yang），国外作者给出全名。
作者单位：作者姓名下面写工作单位、省、市和邮政编码，作者不是同一工作单位时，在作者姓名右上角及工作单位前均加“1”，“2”等标明。
摘要书写方式：按结构式摘要格式书写摘要内容，内容包括Aim、Methods、Results（主要数据）和Conclusion，缩写在第一次出现时需给出全称。
关键词：3～5个关键词置摘要之后，之间用分号(,）尽可能与最新的Medical Subject Headings(MeSH) in Index Medicus相一致。
截稿日期及投稿方式：2008年9月20日。将摘要的Word文件用电子邮件发至2008bsan@imm.ac.cn，并于来信主题中著名“2008国际衰老会”。
请作者务必按格式要求书写论文摘要并按时提交。
摘要示例：
A MODEL OF SUBARACHNOID HEMORRHAGE IN RATS
LI Liao-liao , WANG Xiao-liang*
(Department of Pharmacology, Institute of Materia Medica, Chinese Academy of
Medical Sciences, No.1 Xian Nong Tan Street, Beijing 100050, China)
AIM To build a simple and repeatable animal model of SAH. METHODS SAH was introduced by passing a nylon thread up through the right internal carotid artery and piercing a hone in the right anterior cerebral artery. At 12 and 24h, the rats were evaluated with rotarod test and the behavior scale (5-point scale). RESULTS The rats were trained through rotarod test and then randomly divided into three groups, including vehicle group treated with vehicle after SAH, nimodopine treated group (i.p 0.25mg/kg 5min, 6h, 12h after SAH ) and sham group.At the point of the perforation there was usually a capping clot. There was always blood in the basal cisterns with some spread over the hemisphere. The time of rotarod test at 12h was as follows (mean ± S.E.V): vehicle(n=5), 40±22s; nimodopine(n=5), 121±49s; sham (n=8), 260±89s(P=0.001 overall; P=0.002, vehicle versus sham; P=0.043, nimodopine versus sham). The time of rotarod test at 24h was as follows(mean ± S.E.V): vehicle (n=5), 27±18s; nimodopine(n=5), 73±34s; sham(n=8), 184±45s(P=0.03 overall; P=0.025, vehicle versus sham). The values for the 5-point scale at 12h were as follows(mean ± S.E.V): vehicle(n=5), 2.4±0.5s; nimodopine(n=5), 1.6±0.5s; sham (n=8), 0±0s(P=0.000 overall; P=0.023, vehicle versus sham; P=0.007, nimodopine versus sham). The values for the 5-point scale at 24h were as follows(mean ± S.E.V): vehicle(n=5), 3.2±0.8s; nimodopine(n=5), 1.8±0.4s; sham(n=8), 0±0s(P=0.000 overall; P=0.003, vehicle versus group; P=0.044, vehicle versus nimodopine). CONCLUSION We present a simple and reliable model of SAH in the rats which allows to evaluate novel compounds and new drugs for treatment of SAH.
Key words: animal models, subarachnoid hemorrhage, rats